Animal Model Recapitulates

A large animal model of disc degeneration was established that recapitulates the spectrum of structural compositional and biomechanical features of human disc degeneration this model may serve as a robust platform for evaluating the efficacy of therapeutics targeted towards varying degrees of disc degeneration

Objective the objective of this study was to establish a large animal model that recapitulates the spectrum of intervertebral disc degeneration that occurs in humans and which is suitable for pre clinical evaluation of a wide range of experimental therapeutics design degeneration was induced in the lumbar intervertebral discs of large frame

Second animal models are often used to study the beneficial effects of chronic exercise conditioning on the heart in humans regular exercise is associated with improved cardiovascular function and reduced risk of cardiovascular disease 1 animal models have provided valuable insights into the beneficial and therapeutic changes in cardiovascular physiology and function that result from

Conclusions a large animal model of disc degeneration was established that recapitulates the spectrum of structural compositional and biomechanical features of human disc degeneration

Doi 10 1016 j joca 2016 08 006 corpus id 3755642 a large animal model that recapitulates the spectrum of human intervertebral disc degeneration article gullbrand2017ala title a large animal model that recapitulates the spectrum of human intervertebral disc degeneration author sarah e gullbrand and neil r malhotra and thomas p schaer and zosia zawacki and john t martin and justin

Np11 histologically the spectrum of degeneration achieved in this model recapitulates the range of structural and compositional al terations to the disc observed in human degeneration including a progressive reduction in disc height loss of proteoglycans in the np brosis of the np matrix and disorganization of the af5

The efficient study of human disease requires the proper tools one of the most crucial of which is an accurate animal model that faithfully recapitulates the human condition the study of

Introduction there is currently a major human pandemic caused by the novel severe acute respiratory syndrome sars coronavirus 2 sars cov 2 that leads to coronavirus induced disease covid 19

There is a lack of high fidelity animal models that faithfully recapitulate the hfpef phenotype owing primarily to the disease heterogeneity which has hampered our understanding of the complex

Current animal models such as rdh5 mice fail to recapitulate the functional or degenerative phenotype addressing this need for a relevant animal model we present a new domestic cat model with a loss of function missense mutation in rdh5 c 542g t p gly181val

The aim of this work was to characterize the long term effects of high fat diet induced obesity on the mice cardiovascular system in order to make available a new animal model for diabetic cardiomyopathy methods results male c57bl 6 mice were fed with a standardized high fat diet obese or regular diet normal for 16 months metabolic

The absence of effective countermeasures is the result of multiple factors including the lack of an immunocompetent animal model that recapitulates human disease the paucity of information

Gullbrand se malhotra nr schaer tp zawacki z martin jt bendigo jr milby ah dodge gr vresilovic ej elliott dm mauck rl smith lj 2016 a large animal model that recapitulates the spectrum of human intervertebral disc degeneration osteoarthritis and cartilage pmid 27568573

As with many diseases animal models are critical to establish cause and effect relationships between disease and microbiota while studies with rodent models can be performed using genetically

Abstract β thalassemia an autosomal recessive blood disorder that reduces the production of hemoglobin is majorly caused by the point mutation of the hbb gene resulting in reduced or absent β globin chains of the hemoglobin tetramer animal models recapitulating both the phenotype and genotype of human disease are valuable in the

Conclusions a large animal model of disc degeneration was established that recapitulates the spectrum of structural compositional and biomechanical features of human disc degeneration this model may serve as a robust platform for evaluating the efficacy of therapeutics targeted towards varying degrees of disc degeneration

The theory of recapitulation also called the biogenetic law or embryological parallelism often expressed using ernst haeckel 39 s phrase ontogeny recapitulates phylogeny is an historical hypothesis that the development of the embryo of an animal from fertilization to gestation or hatching goes through stages resembling or representing successive adult stages in the evolution of the

A new article reports the first animal model that recapitulates the severe and sometimes lethal respiratory symptoms seen in human patients and suggests that the common marmoset will play an

Knockout animal models targeting different regions of ano5 gene have been generated previously while deletion of the first two exons of ano5 results in no detectable muscle deficits 23 39 ano5 disruption in mouse by insertional deletion of exons 8 9 results in notable muscle pathology 37 and deletion of exons 11 12 leads to

Current animal models such as rdh5 mice fail to recapitulate the functional or degenerative phenotype addressing this need for a relevant animal model we present a new domestic cat model with a loss of function missense mutation in rdh5 c 542g t p gly181val as with patients affected cats have a marked delay in recovery of dark

Indeed the animal models of diabetic complications consortium currently encourages scientists to propose new animal models of diabetic cardiovascular complications the availability of a validated and comprehensively characterized animal model of diabetic cardiomyopathy will be useful not only to better understand the disease but also to test

Abstract studies in animal models form the basis for much of our current understanding of the pathophysiology of asthma and are central to the preclinical development of drug therapies no animal model completely recapitulates all features of the human disease however research has focused primarily on ways to generate allergic inflammation

Our understanding of crs and neurologic toxicity has been significantly limited by the lack of animal models that faithfully recapitulate these symptoms we chose the non human primate nhp macaca mulatta given that it closely recapitulates the human immune system to create an animal model of b cell directed car t cell therapy targeting cd20